zdatabase. org Precedex for Anesthesia providers: Precedex binds to pre-synaptic alpha 2 receptors, inhibiting norepinephrine and catecholamine release (Increased doses can bind to postsynaptic receptors 1 94% protein bound (caution in hepatic patients, dose reduction should be considered) 2 Reduces inhalational anesthetic requirement (MAC) 3 Onset 10-15 minutes (Give Early depending on when you want to